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Comparison of T3SS components and effectors in various bacteria

 

SALTY

YEREN

SHIFL

EPEC

PSEAE

RALSO

Flagella

 

SPI-1

SPI-2

Ysc

Ysc

 

 

 

 

 

Proto-channel components (inner membrane exporter/translocase)

1

SpaP

SsaR

YscR

YsaR

Spa24

EscR

PscR

HrcR

FliP

2

SpaQ

SsaS

YscS

YsaS

Spa9

EscS

PscS

HrcS

FliQ

3

SpaR

SsaT

YscT

YsaT

Spa29

EscT

PscT

HrcT

FliR

4

SpaS

SsaU

YscU

YsaU

Spa40

EscU

PscU

HrcU

FlhB

5

InvA

SsaV

LcrD

YsaV

MxiA

EscV

PcrD

HrcV

FlhA

6

InvC

SsaN

YscN

YsaN

Spa47

EscN

PscN

HrcN

FliI

Basal body components (periplasmic rings)

1

PrgK

SsaJ

YscJ

YsaJ

MxiJ

EscJ

PscJ

HrcJ

FliF

2

PrgH

SsaK?

YscL? YscD?

?

MxiG

SepL

?

?

FliM?

3

SpaO c

SsaQ

YscQ

YsaQ

Spa33

EscQ

PscQ

HrcQ

FliY (FliN+FliM)

4

InvE c

SpiB?

LcrE? (YopN)

YsaW

MxiC , MxiN?

SepQ?

PscD?

HrpW?

FliG?

Outer ring components (outer membrane secretin)

1

InvG

SpiA?

YscC

YsaC

MxiD

EscC

PscC

HrcC

FlgI?

2

InvH d

SsaO?

YscW? YscO?

?

MxiM

Orf15?

PscI?

?

FlgH

Needle components

1

PrgI

SsaG?

YscF?

 

MxiH

EscF?

PscF?

HrpX?

FlgE?

2

PrgJ e

SsaP?

YscI?

YsaI

MxiI

Orf12?

PscI?

HrpY or K?

FlgD?

3

InvJ f

SsaK? SseI?

YscP?

?

Spa32?

?

PscP?

HrpF?

FliK

Chaperones b

1

PipC

SseD

YscY

YsaH

IpgF

Orf12

PscB

HrpD?

FliT?

2

InvI

SsaO SseE

YscB YscO

?

Spa13?

Orf15?

PscO?

HrcP?

FliJ?

3

SicA

SscB?

LcrH?

?

IpgC?

Orf27?

PscB PscH?

HrpP?

FliS?

4

?

SsaK?

YscL?

?

MxiN?

?

PscL?

HrpF?

FliH?

5

InvB

?

YscG?

YsaK?

Spa15?

?

?

?

?

6

?

SscA?

YscK

?

MxiK

?

?

 

 

Effector proteins b (exoprotein/translocator/host cell membrane translocator)

1

SipA

SseJ?

LcrV?

?

IpaA

EspA?

PepA?

HrpK?

FliC?

2

SipB

SseC?

YopB?

?

IpaB

EspD?

PepB?

HrpV?

FlgK?

3

SipC

SseG?

YopD?

?

IpaC

EspB?

?

HrpJ?

?

4

SipD

SseI?

YopH?

?

IpaD

EspB?

?

HrpL?

FlgL?

5

SptP

?

YopE?

?

?

?

?

?

?

 

Proteins in bold letters have already been identified or indicated by other methods, and the others are candidates picked by my method. Those with the question mark have a few more candidates, but only the strongest candidate(s) are indicated. When candidates are too many to mention, the column was left blank with a question mark.

 

a S. typhimurium has two sets of TTSS (SPI1 and SPI2) on the chromosome. Y. enterocolitica also has two sets of TTSS: the ysc genes on a plasmid and the ysa genes on the chromosome.

bChaperones and effector proteins are not complete, because the number differs from species to species.

cNeither SpaO nor InvE has been found in the preparation of NC.

dInvH is responsible for the penetration of the outer membrane.

ePrgJ is a minor protein of NC. It could be a rod of NC.

fInvJ is not a structural protein, but it is responsible for length control of the needle. For details, see [27] .